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Virmatra Scala Illustrator. Xavier Couperin. Scott E Flanagan Editor. Gudrun Lindstrom. Carl Lindant. Clarice Darling. Rebecca Sharp. Charlotte Glendinning. James Grosvenor. Elliot Freund.

Memorable Projects of 2018. Part 2

Toby Melia. To add more books, click here. Welcome back. In the light of recent developments of how to improve research reporting, it becomes evident that current guidelines such as Gold standard publication checklist, the ARRIVE-guidelines, and recently published PREPARE-guidelines, need reinforcement and implementation in current practice.

Therefore, the LA-day tries to underline the importance of reporting research at all levels, planning, execution and reporting research data. Such guidelines are important to improve publication of research data, but may help at early stages of research, such as review of relevant literature. At the center for any research project is the planning of experiments and optimal experimental design and formulating a working hypothesis.

INTRODUCTION

This is as well essential for preparing grant proposals, for funding, for obtaining appropriate licenses and ethical approval. Furthermore, it favors research reporting of preclinical research and publishing research data, which in turn primes funding. The LA day is organized in four sessions that focus on knowledge of literature, on experimental design, on guidelines and scientific reporting, on sponsoring and editorial aspects, on publication of laboratory animal research data and on ethical concerns in publishing animal welfare data. This event is sponsored by LAL. By facilitating guidance on performing systematic reviews of animal studies, awareness is created on how to enrich research when doing animal studies, e.

Teaching systematic reviews of animal studies takes place in one-day hands-on workshops and providing coaching to participants during the course of performing their own systematic review. Participants rated workshops 8 or higher 10 point scale. Results of these reviews clearly demonstrate where value in research can be increased: comprehensive search of all relevant literature, more evidence-based selection of suitable animal models, transparency on quality of reporting and translation, and summary of the evidence of animal studies before embarking on clinical trials.

Adrian Smith 1 , R. Clutton 2 , E.

Lilley 3 , K. Hansen 4 and T. Brattelid 5.


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Poor reporting, despite extensive endorsement of the ARRIVE guidelines, is often highlighted when the poor reproducibility of animal research is debated. Improved reporting is frequently promoted as the most important method of raising standards. There is an elephant in the room, however, which has received too little attention. Reporting guidelines cannot improve the intrinsic quality of experiments which have already been performed.

Systematic improvement of animal research must begin with guidelines for planning experiments. This approach will also advance the implementation of the 3Rs. Although they contain many of the elements mentioned in reporting guidelines, they also highlight issues which are seldom reported. Many of these can have major effects on the scientific validity of the research, animal welfare and the safety of all those involved.

PREPARE has a point checklist, but more importantly, the website offers scientists links to the latest guidelines for each topic. We hope that the debate about reporting will rotate more towards the planning of animal experiments. If not, we are discussing the quality of the lock on the stable door after the horse has bolted. This is ethically important in order to ensure that the use of animals will make a worthwhile contribution to the knowledge base. However, this can prove challenging as the quality and format of the information provided can vary widely.

The EDA assists researchers in addressing the common problems encountered when designing and analysing animal experiments; it provides approaches that can be used to address these, and highlights where improvements are still to be made. Research is fast, research has to be competitive and laboratory work is time-consuming, challenging and strenuous.

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serving sreelatha part two of three Manual

Key competencies of scientists regularly peak where it comes to quick understanding of complex biomedical contexts and their creativity in asking new questions. The management of projects, resources, and teams is usually not part of the curriculum of scientific training and of lesser significance during a scientific career. However, the lack of project management capabilities leads to insufficient experimental design causing what we now experience as a lack robustness of published data and the reproducibility crisis, which does not seem to come to an end.

We have to accept that through a better test design we achieve better results and at the same time better animal welfare. Intensive preparation and planning leads to a win-win situation. The credibility crisis of biomedical research makes it increasingly difficult to justify animal experiments. A lack of openness makes results worthless. They are questioned by the industry, they do not stand up to critical scrutiny and rightly lead to a loss of confidence in the public, which is usually already opposed to animal testing.

Only meticulously planned and transparently communicated and published animal experiments make it possible to generate robust data. We need to aim for deriving the optimum benefit from animals that are as little burdened as possible. Only in this way can experiments be ethically justified and only in this way can they meet the legitimate demands of the critical public.

The goal of improving the quality of animal research reporting is one that is shared across the laboratory animal sciences. In theory it is fairly simple to achieve on a personal level once an individual is familiar with and understands how to use the free tools and resources that exist to support them to achieve this.

Thus for several years a number of individuals and organisations across Europe and beyond have worked independently to improve the quality of animal research reporting.

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However recent studies have shown that the rate at which the overall quality of animal research reporting is improving is not as rapid as hoped 1. The factors currently limiting the rate of change will also be discussed along with some suggestions as to how through collaborative action we can all help drive culture change and increase the rate at which the quality of animal research reporting can be improved. Dr Nikki Osborne was co-convenor of a roundtable meeting held in September to discuss how to enhance the rate at which the quality of reporting animal research can be improved.

She has published several research and opinion papers relating to journal publication policies and their reporting requirements for animal studies, and was also a member of the ICLAS harmonisation of animal research reporting standards working group that published HARRP. The contribution discusses the problems of gender bias in biomedical research, its causes and consequences for quality of science and clinical medicine.

The gender bias in biomedical research has detrimental consequences for women's health and the quality of science, because it produces bias knowledge and limits successful translation of research outcomes to the clinical practice. Uneven prevalence of several diseases e. However in general, female mammals have been neglected in biomedical research, because of the concern that hormonal cycles decrease the homogeneity of studied populations and therefore influence the research outcomes.

Widespread prevalence of sex differences in human diseases ultimately requires detailed experiments performed on both sexes. Even though the funding agencies encourage enrolment of female mammals, single male sex studies still predominate in the research literature. Beside the questionable quality of research performed on one sex only, there are also ethical issues concerning the female mammals produced in animal breeding facilities. This talk does not aim to provide answers to questions. Instead it is hoped that it will be thought provoking and inspire consideration of the wider role of veterinary surgeons.

Reproducibility has become a standard agenda at CPD meetings, workshops and within institutions.


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